Slide 1: 60M with recent admission for afib w/ RVR… CC: progressive nausea and vomiting. [EKG] What’s the Dx?

Slide 2: This is…digoxin effect! Here is the classic Dali’s mustache (scooped ST segments) -> [EKG] But what else do you see?

Slide 3: There’s AV dissociation here…this is complete heart block! [EKG annotated with atrial tachycardia and regular RR intervals] The escape rhythm…a classic right bundle and therefore likely supraventricular, but can’t be sure it’s not ventricular without a baseline. And an S1, Q3, T3!

Slide 4: Digoxin has 2 unique properties. 1. Inhibits the Na+/K+ ATPase and increases the intracellular Ca2+ -> less negative resting potential -> increased inotropy and automaticity of myocytes. 2. Parasympathetic effect and increased vagal tone -> slows SA and AV conduction. These 2 properties combined can lead to… 1. Atrial arrhythmias with heart block. 2. Ventricular tachyarrhythmias.

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