Slide 1: Making ventilator adjustments: the arterial blood gas. There are four variables we can adjust, each of which fall under two categories. Oxygenation –> affects PaO2. Ventilation –> affects PCO2. A normal PaO2 is ~100 and a normal PaCo2 is ~40. Our targets for ARDS are different. GOal PaO2 > 55 (LOCO2 trial) and goal PaCO2 40-50.

Slide 2: Let’s practice with some ABGs! Answers in the next image!

Slide 3: Answers to the example ABGs. ABG abnormalities responsible for the vent settings have been marked.

Slide 4: Answers to the example ABGs. ABG abnormalities responsible for the vent settings have been marked.

References

  • Barrot L et al. Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome.
    N Engl J Med. 2020 Mar 12;382(11):999-1008. PMID 32160661.

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