Slide 1: Question. The name of which disease is also the longest word in the English language according to Oxford English Dictionary?
Slide 2: Answer. Pneumo-ultra-microscopic-silico-volcano-coniosis
Slide 3: This is a type of lung disease related to the inhalation of silica dust from volcanic ash.
Slide 4: Phagocytosis of silica by alveolar macrophages leads to apoptosis-mediated alveolar inflammation which is thought to contribute to severe lung fibrosis seen in silicosis.
Slide 5: Like many other fibrotic lung diseases, silicosis has no targeted treatments that alter the disease course other than avoiding further exposure to smoke and particulate matter.
- Rimal B, Greenberg AK, Rom WN. Basic pathogenetic mechanisms in silicosis: current understanding. Curr Opin Pulm Med. 2005 Mar;11(2):169-73. PMID 15699791.
Tags: alveolar macrophages, lung disease, silicosis, trivia tuesday, volcano