Slide 1: Question. The name of which disease is also the longest word in the English language according to Oxford English Dictionary?

Slide 2: Answer. Pneumo-ultra-microscopic-silico-volcano-coniosis

Slide 3: This is a type of lung disease related to the inhalation of silica dust from volcanic ash.

Slide 4: Phagocytosis of silica by alveolar macrophages leads to apoptosis-mediated alveolar inflammation which is thought to contribute to severe lung fibrosis seen in silicosis.

Slide 5: Like many other fibrotic lung diseases, silicosis has no targeted treatments that alter the disease course other than avoiding further exposure to smoke and particulate matter.


  • Rimal B, Greenberg AK, Rom WN. Basic pathogenetic mechanisms in silicosis: current understanding. Curr Opin Pulm Med. 2005 Mar;11(2):169-73. PMID 15699791.

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