Behind the Scenes Videos
Key Points:
- Factor V Leiden and Prothrombin gene mutation genetic tests
- Generally accurate in absence of recent blood transfusions
- Antithrombin deficiency assay
- False positive in presence of heparin or with large clot burdens
- False negative in presence of DOAC (Factor 10 based assay)
- Protein C deficiency assay
- False positive with liver dysfunction, Warfarin
- Protein S deficiency assay (antigen and functional assays available)
- False positive with liver dysfunction, Warfarin
- Testing for anti phospholipid syndrome may be warranted, as this may prompt treatment with Warfarin to prevent recurrent arterial events
In this video, Dr. Bauer’s shares his nuanced insight into the clinical circumstances that should impact how thrombophilia tests are interpreted. Each test can be interpreted differently based on several important patient factors! For an even more comprehensive of factors to consider when considering these tests, check out the graphics that accompany the hypercooagulability episode on our website!
Key Points:
- Inherited thrombophilias are present in less than 10% of US population.
- Common tests: Protein C, protein S, antithrombin activity Genetic testing for factor V leiden, prothrombin gene mutations
- Who may benefit from testing? Women on OCPs or pregnant with strong family/personal history.
- Otherwise, testing typically does not change management.
Dr. Connors is a hematologist who explains the clinical circumstances when testing for inherited thrombophilias may be helpful. She emphasizes that these situations are actually quite rare. When in doubt, reach out to your local hematologist!
To learn more about hypercoagulability and how to work-up a patient with a new clot, check out the full Hypercoagulability Work-up 5-Pearls episode at our website! You can also check out more videos like this one by subscribing to our YouTube Channel. Thanks for watching!
Full Episode
Hypercoagulability Workup: Five Pearls Segment